Creutzfeldt-Jakob Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Creutzfeldt-Jakob Disease, including details on mad cow disease, symptoms, causes, variants.

Neuroimaging findings in human prion disease.

Macfarlane RG, Wroe SJ, Collinge J, Yousry TA, Jäger HR

MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, London, UK. r.macfarlane@prion.ucl.ac.uk

Imaging occupies an important role in the investigation of dementia and neurodegenerative disease. The role of imaging in prion disease used to be one of exclusion of other conditions. Over the past decade, the non-invasive nature of MRI, the improved range of magnetic resonance sequences and the availability of clinical and neuropathological correlation have led to a more prominent position of MRI and its inclusion in the diagnostic criteria for variant Creutzfeldt-Jakob disease. As experience of imaging in human prion disease increases, patterns of change related to strain and genotype may improve the diagnostic potential of imaging in the future, may reduce the need for more invasive testing and prove useful in future therapeutic trials. This paper reviews the current knowledge of imaging appearances in human prion disease.

Published 18 June 2007 in J Neurol Neurosurg Psychiatry, 78(7): 664-70.
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